The key requirements of ISO 9001:2015 include addressing seven key areas or clauses: Context of the organization, Leadership, Planning, Support, Operation, Performance evaluation, and Improvement. The main differences from the previous version include the introduction of a risk-based approach, the removal of mandatory procedures, new clauses about the context and interested parties, and increased commitment from top management to the Quality Management System (QMS). Additionally, the structure has changed from 8 to 10 clauses, aligning better with other standards like ISO 14001 and ISO 27001.